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Oligo modifications

IDT offers a vast range of oligo customization options, including fluorophores, dark quenchers, modified bases, linkers, spacers, click chemistry, and more.


A wide variety of modifications can be incorporated into an oligo at the time of synthesis. Some modifications, however, must be attached after synthesis, using NHS Ester chemistry. These post-synthesis modifications often result in lower yields, as they require HPLC purification.

For detailed information about the modifications we offer, click on any of the categories above. Note that not all modifications are available for all types of products and sequences. If the modification you need is not listed, please contact us.

*RUO—For research use only. Not for use in diagnostic procedures. Unless otherwise agreed to in writing, IDT does not intend for these products to be used in clinical applications and does not warrant their fitness or suitability for any clinical diagnostic use. Purchaser is solely responsible for all decisions regarding the use of these products and any associated regulatory or legal obligations.